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The images below show transfected cells (in vitro-left) and in brain slices with spectral conformation (in vivo-right). The image at the bottom is from a Stroke model that show spectral conformation of FeOx nanoparticles appended with flourescent proteins in the brain after a stroke.

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Magnetic nanoparticles leap from lab bench to breast cancer clinical trials ... A new electronic device can developed at the University of Michigan can directly model the behaviors of a synapse ...

A DNA-based dendrimer of the fifth generation in a solution with its counterions. Regular voids in the ineterior of this molecule can be used as transport cages for nanoparticles.

Our group has been working on developing new forms of magnetic nanoparticles for use in cancer treatments. One of classical application is magnetic hyperthermia cancer therapy using an external ac magnetic field and magnetic nanoparticles to control the site-specific targeting and heating.

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In our lab, we use both computational and experimental techniques to understand the phase behavior and self-assembly of nanoparticles in polymer/nanoparticle blends. In a recent work (Figure), we observed that the spatial arrangement of 'bare' nanoparticles in a polymer matrix can be controlled by adding polymer-grafted nanoparticles.

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Researchers used a mouse pneumonia model to demonstrate how a nanoparticle-based technique could be used to detect Pseudomonas aeruginosa bacteria in infected animals and monitor bacterial clearance from their lungs during the course of antibiotic treatment.

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However, after we make them, nanoparticles are screened in cell culture, even though systemic drug delivery is extremely difficult to model in a plastic dish. Now, using high throughput microfluidics and DNA barcoding, we can study how hundreds of LNPs work in a single mouse for the first time.

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From knowledge of the dispersion and distribution of the nanofillers, as well as the relaxation times of the polymers in the nanoparticle/matrix interfacial region, a 3D continuum model can be used to predict the thermomechanical response of the resulting nanocomposites.

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